The reference site for Alteplase

Alteplase is a prescription medication used to break up or dissolve blood clots.

WHAT IS ALTEPLASE?

Alteplase is used to treat people who have suffered heart attacks (acute myocardial infarctions), strokes, chest pain at rest (unstable angina), blood clots in the lungs (pulmonary thrombosis or embolism), and other less common conditions involving blood clots.

Alteplase is an enzyme that occurs naturally in man and causes blood clots to dissolve. It is a man-made protein manufactured by recombinant DNA technology. The naturally occurring protein, known as tissue plasminogen activator (TPA), is made by ovarian cells from the Chinese hamster. Nevertheless, the amount that is given to patients is far greater than the amount naturally made by the body itself.

Brand Name(s): Activase; TPA

CAS nº: 105857-23-6

(al-te-plase)

Product Info

The sections below will provide you with more specific information and guidelines related to fluoxetine and its correct use. Please read them carefully.

FDA Information

Alteplase was first approved for heart attacks in 1987. In 1996, it was approved for strokes. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Alteplase is used in the treatment of heart attacks (acute myocardial infarctions), strokes, chest pain at rest (unstable angina), blood clots in the lungs (pulmonary thrombosis or embolism), and other less common conditions involving blood clots.

Alteplase is an enzyme that occurs naturally in man and causes blood clots to dissolve. It is a man-made protein manufactured by recombinant DNA technology. The naturally occurring protein, known as tissue plasminogen activator (TPA), is made by ovarian cells from the Chinese hamster.

However, the amount that is given to patients is far greater than the amount naturally made by the body itself.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Activase® (alteplase) is for intravenous administration only. It is important that you consult your doctor or pharmacist on how to use the medication correctly and follow all instructions carefully.

Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.

Mix Activase® by injecting 2.2 ml of sterile water for injection into the vial. Do not use a mixing solution containing a preservative (e.g., bacteriostatic water).

Gently swirl the vial until the drug is completely dissolved. Do not shake the vial.

Slight foaming or bubbles may be present. If any large bubbles are present, allow them to dissolve before drawing the solution into a syringe. If any of the mixing instructions are unclear, consult your pharmacist.

Inject this medication into the blocked IV line as directed by your doctor. The dosage is usually 2 mg (1 vial).

Avoid injecting this drug too quickly or with too much force/pressure. Doing so may damage the IV line or cause the blood clot to go into the blood stream.

If the IV line does not re-open within 2 hours of the first dose, a second dose may be placed into the IV line. However, please consult this with your doctor.

Depending on the condition being treated, it is given once quickly or as a brief infusion over 30 to 60 minutes.

What special precautions should I follow?

BEFORE TAKING ALTEPLASE:

Inform your doctor of all prescription and non-prescription medication you may be using, especially: “blood thinners” (e.g., Warfarin®), or aspirin.

Tell your doctor your medical history, especially if you have had: recent surgery or medical procedures (e.g., biopsies, blood tests), recent childbirth, liver problems, kidney problems, blood disorders (e.g., low platelets) or any allergies.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

Furthermore, it is not known whether alteplase passes into breast milk. Consult your doctor before breast-feeding.

What should I do if I forget a dose?

Continued or repeated doses are usually not necessary for this medication.

What side effects can this medication cause?

Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.

No side effects are expected to occur. However, if any side effects do occur, notify your doctor immediately.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

dizziness
lightheadedness
persistent sore throat or fever

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur:

weakness on one side of the body
black stools
unusual bruising or bleeding
pain and/or swelling in the lower legs/arms/groin
trouble breathing

If you notice other effects not listed above, contact your doctor or pharmacist.

What storage conditions are needed for this medicine?

Store the unmixed vials refrigerated between 36 and 46 degrees F (2 and 8 degrees C) away from light. Do not freeze.

Once mixed, the solution is good for 8 hours either refrigerated or at room temperature (between 36 and 86 degrees F or 2 and 30 degrees C). Remember to discard any unused portion of the vial(s).

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, then please call the local emergency services on 911.

The main symptom of an overdose is unusual bleeding.

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